Barigen (Baricitinib)
Barigen contains baricitinib, a prescription medicine belonging to a group of medicines called Janus kinase (JAK) inhibitors. Baricitinib works by reducing the activity of certain immune-system signals involved in inflammation. In simple terms, it helps calm an overactive immune response.
What is Barigen used for?
Baricitinib may be prescribed for certain inflammatory and autoimmune conditions, including:
- Rheumatoid arthritis (RA): for adults with moderate-to-severe active disease when previous treatment, such as TNF-inhibitor therapy, has not worked adequately.
- Alopecia areata: severe autoimmune hair loss in adults, where approved.
- Certain hospitalized COVID-19 patients: in specific situations requiring supplemental oxygen or advanced respiratory support, according to applicable treatment guidelines and approvals.
How does Barigen work?
Baricitinib selectively and reversibly inhibits JAK1 and JAK2 enzymes. These enzymes help transmit signals from inflammatory cytokines. By reducing JAK1/JAK2 signaling, baricitinib can decrease inflammation and excessive immune activity.
How is it taken?
Baricitinib is an oral tablet and is generally taken once daily, with or without food. The appropriate strength and dose depend on the condition being treated, kidney function, other medicines, and the individual patient’s circumstances. For rheumatoid arthritis, a commonly recommended adult dose is 2 mg once daily, but the prescribing physician should determine the dose.
Do not change the dose or stop Barigen without medical advice.
Important safety information
Because Baricitinib suppresses part of the immune system, it can increase the risk of serious infections, including tuberculosis. It has also been associated with risks such as certain cancers, blood clots, and major cardiovascular events. These risks are particularly important in some higher-risk patients.
Doctors may therefore assess factors such as:
- Existing or recent infections
- Tuberculosis risk
- Blood counts
- Liver function
- Kidney function
- Cholesterol/lipid levels
- History of blood clots or cardiovascular disease
- Other medicines being taken
Live vaccines should generally be avoided during treatment unless specifically advised by a healthcare professional.
Common side effects
Possible side effects can include upper-respiratory infections, nausea, headache, acne, and changes in laboratory blood-test results. More serious symptoms—such as persistent fever, severe infection symptoms, chest pain, shortness of breath, or sudden swelling/pain in a limb—require prompt medical attention.
Important
Barigen is a prescription immunosuppressive medicine and should be used only under the supervision of a qualified physician. It is not appropriate for everyone, and the correct dose depends on the patient’s diagnosis and medical history.
This information is for general education and does not replace the prescribing information or advice from a doctor or pharmacist.